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KMID : 0369819950250040339
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Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 4 p.339 ~ p.346
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Design of Oral Pathches for the Treatment of Aphthous Stomatitis: Drug Layer
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Abstract
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For the effective treatment of aphthous stomatitis, the matrix type mucoadhesive patches containing triamcinolone acetonide have been formulated. The drug layer was obtained by drying the polymer gel which was prepared with carbomer 934P,
ammoniomethacrylate copolymer, titanium dioxide and polyethylene glycol 400. The effects of the content of additives on physical characteristics of the polymer gel and the drug layer were evaluated. The addition of carbomer increased the yield
point and
the zero-shear viscosity of polymer gel as well as the thickness, the water absorption ratio, the adhesive time and T50% of drug layer. The adhesive time and the water absorption ratio of drug layer were also improved by the addition of
ammoniomethacrylate copolymer, but the addition of titanium dioxide had decreased the zero-shear viscosity of polymergel and the adhesive time of drug layer.
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